In our latest question and answer, the pharmacist discusses whether or not it is safe to take Benadryl, melatonin and Ambien together.

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Jenni asked

Can I take Diphenhydramine and also Melatonin and also Zolpidiem together?


Benadryl (diphenhydramine), Ambien (zolpidem), and also melatonin are not recommfinished to be taken together because of additive sedation andadditive CNS depression. The resulting side effects might be dangerous.

Two or even more of these drugs need to only be taken together under the reference and also supervision of your doctor. Taking all 3 medications together will rise the hazard of:

DizzinessDrowsinessDry mouthDry eyesConstipationRespiratory depression

Of certain note are Benaryl and also Ambien. Both depress the main nervous mechanism and tright here have been reports of respiratory depression on the burning. This could cause labored and shenable breapoint which can be incredibly dangerous, specifically in particular individuals taking otherCNS depressants such as opioids.

Below is some added indevelopment on each medication.

Benadryl (Diphenhydramine)

Benadrylis a sedating antihistamine, supplied a lot of commonly for the treatment of allergic reactions, seasonal allergies, symptoms linked through the widespread cold and insomnia. Benadryl might be taken without regard to meals. Commjust reported side effects connected through taking Benadryl incorporate however are not restricted to:

DrowsinessDizzinessFatigueDry mouthConstipationAmbien (Zolpidem)

Ambien (Zolpidem) is a sedative hypnotic medication and also is obtainable as an immediate release tablet (Ambien) and also as an extended release tablet (Ambien CR). Ambien acts on the GABA receptors which leads to the preferred sedative effects in treating insomnia.

Ambien and also Ambien CR have to both be taken on an empty stomach ideal prior to bedtime as the average onset of action for both the immediate and extended release tablets is 30 minutesThe onset can vary in between individuals and also might be delayed if the medication is taken via food. You have to take the lowest effective dose of Ambien as taking better than necessary doses can cause enhanced threats of side effects. Side effects of Ambien incorporate yet are not limited to:

AnxietyDrowsiness HeadacheDepressionUnusual thoughtsGrogginessDry mouthConstipationIrregular heart rateMelatonin

Melatoninis a normally developed hormone that helps to control our circadian rhythm and also the sleep wake cycle. Although taking melatonin can help through making the body feel exhausted as a climb of melatonin levels mostly shows to our body that it is time to sleep it is not as efficient as other therapies for short term insomnia.

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It is even more efficient in populaces that have reduced melatonin production such as the elderly and also populations that may have actually a disruption to the normal sleep wake cycle such as change workers or individuals suffering from jet lag. Common side impacts connected with taking melatonin incorporate yet are not limited to:

DrowsinessHeadacheStomach crampsFurther Information

If you are still having difficulties resting after having been prescribed Ambien, it is necessary to sheight to your doctor. You might require a dose or medication readjust, or be re-evaluated as to the reason of your insomnia. It mostly is not recommended to include more resting medicines on optimal of it (e.g. Benadryl) if it isn"t working well.